ICSI Cumulase®

ICSI Cumulase^® is used for the removal (denudation) of the cell complex (cumulus and corona radiata) surrounding the oocyte in preparation for ICSI.

Background
Prior to the ICSI procedure, the cells of the cumulus and corona radiata must be removed in order to facilitate access to the oocyte and minimise contamination of the injection needle.

ICSI Cumulase^® is the only ready-to-use recombinant human hyaluronidase (rHuPH20) on the market. In contrast to the conventional animal hyaluronidase extracts, ICSI Cumulase^® carries a number of advantages:

Features	Benefits
Less toxic than best available hyaluronidases	Higher pregnancy rates due to less physical stress, as less mechanical stripping is necessary Exposure time is not critical
Human origin of enzyme	Human enzyme for human oocytes No risk of any viral transmissions and other contaminant problems related to crude animal extracts
Free of any serum components or animal derivatives	Unparalleled in purity and safety
Ready-to-use single-cycle vials	Convenient packaging preventing dilution and pipetting Risk of contamination is eliminated
8 weeks of shelf life	Minimises media wastage

Clinical data
Dr. Peter Nagy, USA presented clinical data at ESHRE 2005, where a bovine-derived hyaluronidase extract was compared to Cumulase^®. Data showed higher embryo score on day 3 and higher fertilisation rates by using Cumulase^®.

Embryo score Day 3	Bovine (competitor product)	Cumulase^TM	26 patients	Bovine (competitor product)	Cumulase^TM
Excellent	44%	61%	Oocytes	203	199
Good	33%	29%	No. of fertilised oocytes	146	162
Adequate	5%	4%	Fertilisation rate	71.9%	81.4%
Poor	18%	6%	Increase in fertilisation rate	-	+13%
Ref: Nagy et al.,Hum. Rep. 20 suppl.1, 2005, O-213			Ref: Press release, June 22, 2005 </ www.halozyme.com?>www.halozyme.com

Package Info

Description	Cat.no.	Size	Shelf life
ICSI Cumulase®	16125000	5x0.5 ml	12 weeks